Deferasirox pharmacokinetics in patients with adequate versus inadequate response
نویسندگان
چکیده
منابع مشابه
Deferasirox pharmacokinetics in patients with adequate versus inadequate response.
Tens of thousands of transfusion-dependent (eg, thalassemia) patients worldwide suffer from chronic iron overload and its potentially fatal complications. The oral iron chelator deferasirox has become commercially available in many countries since 2006. Although this alternative to parenteral deferoxamine has been a major advance for patients with transfusional hemosiderosis, a proportion of pa...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Deferasirox pharmacokinetics in patients with adequate versus inadequate response
1Hematology/Oncology, Children’s Hospital Boston, MA; 2Harvard Medical School, Boston, MA; 3Dana-Farber Cancer Institute, Boston, MA; 4Clinical Pharmacology Unit, Children’s Hospital Boston, MA; 5Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, ON; 6Division of Nuclear Medicine, Children’s Hospital Boston, MA; and 7Novartis Pharmaceut...
متن کاملPharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill Patients
There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...
متن کاملPharmacokinetics and Safety of Deferasirox in Subjects with Chronic Kidney Disease Undergoing Haemodialysis Running title: Deferasirox in chronic kidney disease
Aim: Treatment of chronic kidney disease (CKD) includes parenteral iron therapy, and these infusions can lead to iron overload. Secondary iron overload is typically treated with iron chelators, of which deferasirox is one of the most promising. However, it has not been studied in patients with CKD and iron overload. Methods: A pilot study was conducted to evaluate the pharmacokinetics and safet...
متن کاملPharmacokinetics Alterations of Midazolam Infusion versus Bolus Administration in Mechanically Ventilated Critically Ill Patients
There is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. We prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2009-05-222729